Akane, the Kawaikunē
Tendou Akane is a fictional character created by renowned mangaka Takahashi Rumiko in 1987 with the release of her martial arts episodic comedy series, Ranma 1/2. The youngest of three daughters, at sixteen she found herself engaged out of her will to Ranma Saotome, the son of her father's best friend, in order to assure the union and continuance of the Saotome and Tendou Schools of Martial Arts. The series spans 38 volumes, and revolves around the bizarre and hilarious dynamics of their relationship as they move from reluctance to denial to friendship to love—with the road to romance made more difficult because of Akane's other suitors and Ranma's other fiancées. Not to mention that both Ranma and Akane are perhaps the two most stubborn people in Furinkan (where the manga is set) who absolutely refuse to admit their growing attraction to each other, despite numerous occasions that prove the contrary.
Kawaikunē (かわいくねえ. commonly translated as "uncute") is what Ranma often calls Akane, which she counters with "Ranma no baka" ("Ranma you jerk"). The grammatically correct form is really kawaikunai, but Ranma pronounces it "kawaikunē" in both the manga (specifically Chapter 14, which is its chapter title) and the anime (as in Episode 9).
The term is used both ironically and affectionately as this site title because Akane is not at all "uncute;" she is in fact one of the most attractive girls at her high school, as seen in the first few chapters/episodes when she had to beat down her suitors every morning because only by defeating her could they take her out on a date. (This sets up her character to be perceived as a pretty good martial artist as well.) Ranma calling her by this insult is twofold: it is his way of teasing her by constantly making it appear that he sees her as unfeminine, but at the same time—because Ranma is a classic tsundere who says the opposite of what he actually feels—it is a very clear indication that he is actually attracted to her. There have been so many instances when he has found her cute, but he would rather die than admit it.